Heat a large skillet over medium-high heat. Brown ground beef in skillet until no longer pink, about 8 minutes.
Add Manwich Bold sauce and stir until beef is well coated. Cook for 2 minutes.
Add chile powder, oregano, cumin, onion powder, garlic powder, salt, and pepper to beef mixture; stir to incorporate seasoning into sauce. Cook for two minutes.
Separate burger bun bottoms and tops, with the cut sides facing up. Spread 1 to 2 tablespoon guacamole on the cut side of the top bun.
Spoon 1/4 of the beef mixture onto the cut side of the bottom bun. Top beef mixture with 1/4 of the shredded cheese. Place top bun on cheese, guac side down.
Dig in and try not to get too messy! I like to serve these with some tortilla chips so I can scoop up and sloppy jose that falls onto my plate and eat it with the chips. YUM!