Preheat oven to 300 degrees F. Line a baking sheet with a Sil-Pat or parchment paper.
In a medium saucepan, melt together butter and hot sauce over medium-low heat. Whisk occasionally.
Add Worcestershire sauce, garlic powder, onion powder, and seasoned salt. Whisk to combine.
To a large mixing bowl add pretzels, cheese crackers, and Melba crackers. Pour wing sauce mixture over cracker mixture. Toss with a large spoon until crackers and pretzels are well coated. Let everything sit in the bowl for a couple minutes to soak up the sauce.
Pour cracker mixture onto prepared baking sheet. Spread into an even layer. Bake for 30 minutes, stirring once. After 30 minutes, stir the snack mix once more, and then sprinkle ranch mix over the top. Bake for 5 more minutes. Remove from oven and let cool for 10 minutes. Transfer to a serving bowl and eat. You could also serve ranch or bleu cheese dressing along side as a dip.